MCDB: A comprehensive curated mitotic catastrophe database
July 31, 2021The Mitotic Catastrophe Database (MCDB) is a proprietary, open-source, and comprehensive repository of data on Mitotic Catastrophes (MC). It enables researchers in medicinal chemistry, molecular biology, bioinformatics, and oncology to explore MC.
MC is a type of programmed cell death caused by defects in the mitotic process that plays a role in tumour prevention, development, and treatment resistance. Due to the fact that the availability of MC data is critical for tumor-related scientific and clinical research, the establishment of a professional and complete database to curate MC-related data is becoming a higher priority.
The MCDB contains 1214 genes/proteins and 5014 chemicals that have been compiled and grouped from over 8000 research articles. The MCDB standardises the confidence level, categorization criteria, and naming conventions for MC-related data, significantly improving data reliability and retrievability. Additionally, MCDB develops functions for protein sequence alignment and target prediction. The former can be used to anticipate novel MC-related genes and proteins, while the latter can aid in the identification of unknown MC-related drugs’ target proteins.
MCDB is available at http://www.combio-lezhang.online/MCDB/index_html/
Reference
Le Zhang, Lei Zhang, Yue Guo, Ming Xiao, Lu Feng, Chengcan Yang, Guan Wang, Liang Ouyang, MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction, Acta Pharmaceutica Sinica B, 2021, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2021.05.032
