A tool for alignment of protein interaction networks

PathBLAST is a network alignment and search tool for comparing protein interaction networks across species to identify protein pathways and complexes that have been conserved by evolution.Target protein–protein interaction networks are currently available for Helicobacter pylori, Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster.Partial protein–protein interaction networks are also available for Homo sapiens and Mus musculus.

PathBLAST searches for high-scoring pathway alignments between two paths, one from each network, in which proteins of the first path are paired with putative orthologs occurring in the same order in the second path. Pathway alignments are scored by the degree of protein sequence similarity at each pathway position and by the quality of the protein interactions they contain.

The PathBLAST front page prompts users to specify both the pathway query and the target network.The score of each pathway alignment is also reported with each textual and graphical alignment result.

Go to http://www.pathblast.org/